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DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection
M Yokoyama1, J Zhang, J L Whitton
1Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037.
Journal of Virology
|April 1, 1995
Abstract:
DNA vaccination has been evaluated with the lymphocytic choriomeningitis virus (LCMV) model system. Plasmid DNA encoding the LCMV nucleoprotein, when injected intramuscularly, induces both antiviral antibodies and cytotoxic T lymphocytes. Injection of DNA encoding the nucleoprotein or the viral glycoprotein confers protection against normally lethal LCMV challenge in a major histocompatibility complex-dependent manner. The protection conferred is incomplete, but it is most probably mediated by the induced cytotoxic T lymphocytes.