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Increased serum D-lactate associated with diabetic ketoacidosis
M M Christopher1, J D Broussard, C W Fallin
1Department of Physiological Sciences, University of Florida, Gainesville.
Metabolism: Clinical and Experimental
|March 1, 1995
Summary
Serum D-lactate levels are elevated in diabetic cats, particularly those with ketoacidosis. Hepatic ketone metabolism, not hyperglycemia, appears to be the primary driver of increased D-lactate in diabetic individuals.
Area of Science:
- Metabolic Biochemistry
- Veterinary Internal Medicine
- Endocrinology
Background:
- Diabetes mellitus is associated with metabolic dysregulation.
- Elevated D-lactate has been observed in diabetic states, but its source is unclear.
- Potential sources include glucose metabolism and hepatic ketone production.
Purpose of the Study:
- To investigate the relationship between serum D-lactate and diabetes mellitus in cats.
- To determine whether hyperglycemia or hepatic ketone metabolism is the primary contributor to elevated D-lactate.
- To explore D-lactate levels in diabetic ketoacidosis.
Main Methods:
- Serum D-lactate and beta-hydroxybutyrate levels were measured in diabetic cats and controls.
- Correlation analysis was performed between D-lactate, beta-hydroxybutyrate, and glucose.
- In vitro erythrocyte D-lactate formation was assessed under hyperglycemic conditions.
Main Results:
- Serum D-lactate was significantly elevated in cats with ketoacidosis compared to non-ketoacidotic diabetics and controls.
- A strong positive linear correlation was found between serum D-lactate and beta-hydroxybutyrate.
- Serum D-lactate did not correlate with serum glucose, and hyperglycemia did not increase in vitro D-lactate formation.
Conclusions:
- Hepatic ketone metabolism, rather than hyperglycemia, is a major source of serum D-lactate in diabetic cats.
- Elevated D-lactate may serve as a biomarker for ketoacidosis in diabetic patients.
- Further research into the clinical implications of D-lactate in diabetes is warranted.