[Myocyte proliferation and differentiation in experimentally induced myocardial hypertrophy]

Processes of proliferation and differentiation of cardiomyocytes in control and during the low-temperature incubation of chicken embryos were studied by methods of radiography, cytophotometry, electron microscopy. In normal embryos at different periods of their development in histogenesis of the cardiac muscle tissue of chicken embryos there are periods with prevailing processes of proliferation, dynamic balance of processes of proliferation and differentiation and prevailing processes of differentiation of cardiomyocytes. Under conditions of developing hypertrophy of the myocardium, the regular processes of the development of organization of the myocardium at the cellular and tissue levels remain unchanged as a whole, but they shift in time. The urgent reaction of cardiomyocytes of the embryonic myocardium in the absence of formed tissue mechanisms of regulation of homeostasis is insufficient for the development of the compensation-adaptation and regulation processes in the cardiac muscle tissue, which might be responsible for the development of tissue according to the pathologic type.