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Endometrium preparation with exogenous estradiol and progesterone for the transfer of cryopreserved blastocysts
C Lelaidier1, D de Ziegler, S Freitas
1Department of Obstetrics and Gynecology, Hôpital A. Bećlere, Clamart, France.
Objective:
To determine the implantation rates of cryopreserved blastocysts using controlled E2 and P replacement cycles in women with functioning ovaries.
Design:
Retrospective clinical study.
Setting:
University teaching hospital.
Patients:
Infertile women with cryopreserved blastocysts obtained from previous IVF attempts.
Interventions:
Exogenous E2 was administered orally from cycle day 1 and P was started transvaginally from day 15. Blastocysts were transferred on the 5th day of endometrial exposure to P (day 19).
Main Outcome Measures:
Blastocyst implantation rate and pregnancy rate (PR).
Results:
Ninety-eight percent of blastocysts survived thawing: 67 were transferred in 42 women. Eight pregnancies occurred giving a PR of 19% per ET and 11.9% per blastocyst.
Conclusion:
The high PR observed after transferring blastocysts on the 5th day of endometrial exposure to P in controlled E2 and P replacement cycles speaks for a forward slide of the window of transfer in case of blastocysts.