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Interaction between gamma delta T cells and B cells regulating IgG production
1Institute of Medical Microbiology and Hygiene, Technical University of Munich, Germany.
Immunology
|January 1, 1995
Summary
Gamma delta T cells interact with B cells, with activated B cells stimulating them and activated gamma delta T cells inhibiting B cell IgG secretion. This suggests a regulatory role for gamma delta T cells in immune responses.
Area of Science:
- Immunology
- Cell Biology
Background:
- The precise physiological role of gamma delta T cells remains unclear despite extensive knowledge of their receptor structure.
- Gamma delta T cells are observed at inflammatory sites, suggesting involvement in immune reactions.
Purpose of the Study:
- To investigate the in vitro stimulation of gamma delta T cells by B cells.
- To explore the functional interaction between gamma delta T cells and B cells.
Main Methods:
- Utilizing autologous B-lymphoblastic cell lines (B-LCL) and mitogen-activated B cells for gamma delta T cell stimulation.
- Employing co-culture experiments to assess the impact of activated gamma delta T cells on B cell IgG secretion.
Main Results:
- Autologous B-LCL and activated autologous B cells effectively stimulate gamma delta T cells.
- Gamma delta T cell activation leads to an increase in V delta 1+ T cells.
- Activated gamma delta T cells inhibit IgG secretion by B cells in co-cultures.
Conclusions:
- A reciprocal regulatory interaction between B cells and gamma delta T cells is demonstrated in vitro.
- This interaction provides a potential model to explain in vivo gamma delta T cell activation patterns.