Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuropsychological function in asymptomatic HIV-1 infection: methodological issues

A C Grunseit1, M Perdices, N Dunbar

  • 1National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia.

Journal of Clinical and Experimental Neuropsychology
|December 1, 1994
PubMed
Summary

Asymptomatic HIV-1 infection did not significantly impair neuropsychological performance in this study. HIV-1 positive individuals performed comparably to seronegative controls, suggesting no significant cognitive decline.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells.

Breast cancer research : BCR·2025
Same author

Targeting Unique Ligand Binding Domain Structural Features Downregulates DKK1 in Y537S <i>ESR1</i> Mutant Breast Cancer Cells.

Research square·2024
Same author

Targeting Unique Ligand Binding Domain Structural Features Downregulates DKK1 in Y537S <i>ESR1</i> Mutant Breast Cancer Cells.

bioRxiv : the preprint server for biology·2024
Same author

Personalised treatments for acute whiplash injuries: A pilot study of nested N-of-1 trials in a multiple baseline single-case experimental design.

Contemporary clinical trials communications·2019
Same author

Cardiovascular disease and diabetes in HIV-positive and HIV-negative gay and bisexual men over the age of 55 years in Australia: insights from the Australian Positive & Peers Longevity Evaluation Study.

HIV medicine·2018
Same author

Charge-Induced Force Noise on Free-Falling Test Masses: Results from LISA Pathfinder.

Physical review letters·2017

Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Psychology

Background:

  • Conflicting reports exist on neuropsychological decline in asymptomatic HIV-1 infection.
  • Previous studies faced limitations due to sample size, statistical methods, and definitions of abnormality.

Purpose of the Study:

  • To compare neuropsychological performance between asymptomatic HIV-1 positive and seronegative individuals.
  • To determine rates of neuropsychological abnormality using various criteria in HIV-1 infection.

Main Methods:

  • Neuropsychological performance was assessed in 44 asymptomatic HIV-1 positive subjects and 41 seronegative controls.
  • Analysis of variance models were used for comparison.
  • Commonly employed impairment criteria were used to determine abnormality rates.

Related Experiment Videos

Main Results:

  • HIV-1 positive subjects performed comparably to seronegative controls after accounting for full-scale IQ differences.
  • Abnormality rates for HIV-1 positive subjects were 10%, 17.5%, and 67.5% across three criteria, not significantly different from controls.
  • No significant neuropsychological deterioration was observed in asymptomatic HIV-1 infection.

Conclusions:

  • Premorbid characteristics and the validity of impairment definitions are crucial for interpreting study findings.
  • Careful consideration of confounding factors is necessary when assessing cognitive function in HIV-1 infection.
  • Current findings suggest that asymptomatic HIV-1 infection may not lead to significant cognitive impairment.