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Bilateral diffuse iris nodular nevi. Clinical and histopathologic characterization

B H Ticho1, M Rosner, M B Mets

  • 1Department of Ophthalmology, Children's Memorial Hospital, Chicago.

Ophthalmology
|March 1, 1995
PubMed
Summary
This summary is machine-generated.

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Bilateral diffuse iris nodular nevi are a rare condition presenting as multiple iris excrescences. This study describes 30 patients and their associations with various congenital anomalies.

Area of Science:

  • Ophthalmology
  • Developmental Biology
  • Genetics

Background:

  • Diffuse nodular nevus of the iris is an uncommon condition characterized by multiple verrucous excrescences on the iris surface.
  • This study presents the largest clinical series to date of bilateral diffuse iris nodular nevi.

Observation:

  • Thirty patients with bilateral diffuse iris nodular nevi were analyzed.
  • Associated conditions included congenital cataract, neurofibromatosis, oculodermal melanocytosis, congenital ptosis, and various ocular anomalies (Morning Glory, Axenfeld, Peters).

Findings:

  • Iris nodules were uniformly sized, brown, and diffusely distributed.
  • Microscopy revealed plaques of nevoid cells interwoven with uveal melanocytes, suggesting a neural crest developmental variant.

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Implications:

  • Bilateral diffuse iris nodular nevi represent a distinct entity, potentially a variant of neural crest development.
  • These nodules are clinically distinct from Lisch nodules and other pathological iris lesions.
  • No ocular complications were directly attributed to the iris nodules themselves.