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[Adrenergic response during general anesthesia with propofol as maintenance agent]
E Navas1, J Baena, J C Luis-Navarro
1Servicio de Anestesiología, Reanimación y Terapéutica del Dolor, Hospital Universitario Virgen del Rocío, Sevilla.
Revista Espanola De Anestesiologia Y Reanimacion
|January 1, 1995
Summary
Propofol anesthesia significantly elevates plasma adrenalin and noradrenalin levels in patients undergoing orthopedic surgery. Dopamine levels remained unaffected, while adrenalin returned to baseline within 45 minutes.
Area of Science:
- Anesthesiology
- Pharmacology
- Endocrinology
Context:
- Propofol is a widely used anesthetic agent.
- Understanding its effects on the neuroendocrine system is crucial for patient safety.
- Previous research has yielded mixed results regarding catecholamine responses.
Purpose:
- To quantify plasma catecholamine levels (dopamine, norepinephrine, epinephrine) during propofol-maintained anesthesia.
- To assess the impact of propofol on stress hormone release in surgical patients.
Summary:
- Twenty patients undergoing elective orthopedic surgery received propofol for anesthesia maintenance.
- Plasma catecholamines were measured at baseline, post-intubation, and at 15-minute intervals.
- Norepinephrine levels were significantly elevated throughout the procedure.
- Epinephrine levels showed significant increases initially but returned to baseline by 45 minutes.
- Dopamine levels did not exhibit significant changes.
Impact:
- Total intravenous anesthesia with propofol is associated with significant sympathoadrenal activation.
- Findings highlight the need for careful monitoring of cardiovascular parameters during propofol anesthesia.
- This study contributes to the understanding of propofol's physiological effects in surgical settings.