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Experimental murine schistosomiasis and thyroid function

E S Neves1, J V Santana, E A Araújo

  • 1Departamento de Anatomia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Pernambuco, Recife, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|June 1, 1994
PubMed
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Prepuberal infection with Schistosoma mansoni in mice caused enlarged livers and spleens. However, thyroid function and overall growth remained normal in this experimental hepatosplenic schistosomiasis model.

Area of Science:

  • Parasitology
  • Endocrinology
  • Immunology

Background:

  • Hepatosplenic schistosomiasis in humans can be linked to somatosexual underdevelopment.
  • Understanding the impact of Schistosoma mansoni infection on host development is crucial.

Purpose of the Study:

  • To investigate the relationship between experimental hepatosplenic schistosomiasis and thyroid function in mice.
  • To evaluate the effects of prepuberal Schistosoma mansoni infection on somatosexual development.

Main Methods:

  • Induction of experimental hepatosplenic schistosomiasis in 21-day-old mice using Schistosoma mansoni.
  • Measurement of plasma T3 and T4 levels via radioimmunoassay in 115-day-old male mice.
  • Assessment of liver and spleen weights, and overall animal growth.

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Main Results:

  • Significant increases in liver (74%) and spleen (138%) weights were observed.
  • No significant changes in animal growth or plasma T3 and T4 concentrations were detected.
  • The experimental model successfully replicated the hepatosplenic form of schistosomiasis.

Conclusions:

  • Prepuberal Schistosoma mansoni infection leads to hepatosplenic disease in adult mice.
  • Thyroid function appears to be unaffected by this experimental model of schistosomiasis under the conditions studied.
  • Further research may explore potential subtle developmental impacts or long-term effects.