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Experience with brain abscesses

S Malik1, S M Joshi, P W Kandoth

  • 1Department of Pediatrics and Neurosurgery, T.N. Medical College and B.Y.L. Nair Hospital, Bombay.

Indian Pediatrics
|June 1, 1994
PubMed
Summary
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This study on brain abscesses in 47 patients found otogenic sources and infections were common causes. High mortality rates were linked to severe coma, young age, and multiple abscesses.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Pediatrics

Background:

  • Brain abscesses are serious intracranial infections.
  • Pediatric cases often present with diverse predisposing factors.
  • Early diagnosis and intervention are critical.

Purpose of the Study:

  • To analyze the clinical presentation, etiology, diagnosis, and outcomes of brain abscesses.
  • To identify prognostic factors influencing mortality in brain abscess patients.
  • To evaluate the effectiveness of current treatment strategies.

Main Methods:

  • Retrospective analysis of 47 patients diagnosed with brain abscess.
  • Clinical data collection including demographics, predisposing factors, and symptoms.
  • Diagnostic imaging (CT scanning) and microbiological analysis.

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  • Assessment of treatment protocols and patient outcomes, including mortality.

    • Main Results:

    • The commonest age group was 5-15 years, with otogenic sources being the most frequent predisposing factor.
    • Fever, raised intracranial tension, and altered sensorium were predominant clinical features.
    • CT scanning was crucial for diagnosis; Staphylococci, Proteus, and Pseudomonas were common pathogens.
    • Overall mortality was 44.7%, with Grade III/IV coma, age below 2 years, and multiple abscesses identified as poor prognostic indicators.

    Conclusions:

    • Brain abscesses remain a significant cause of morbidity and mortality, particularly in children.
    • Prompt diagnosis via CT scanning and appropriate antimicrobial and surgical management are essential.
    • Identifying and addressing poor prognostic factors can potentially improve patient outcomes.