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Fatal lorcainide poisoning

J Evers1, U Büttner-Belz

  • 1Medizinische Klinik, Kliniken Köln-Merheim, Germany.

Journal of Toxicology. Clinical Toxicology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

A 15-year-old girl experienced fatal lorcainide poisoning after ingesting 2500 mg of this antiarrhythmic agent. Her rapid decline into bradycardia, shock, coma, and seizures, despite resuscitation, highlights the severe toxicity of lorcainide.

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Area of Science:

  • Cardiology
  • Clinical Toxicology
  • Pharmacology

Background:

  • Lorcainide is a Class Ic antiarrhythmic agent.
  • Antiarrhythmic drug toxicity can lead to severe cardiovascular events.
  • Understanding overdose effects is crucial for emergency treatment.

Observation:

  • A 15-year-old female ingested a significant overdose of lorcainide (2500 mg).
  • The patient rapidly developed severe symptoms including bradycardia, shock, coma, and seizures.
  • Despite aggressive resuscitative measures, including catecholamines and sodium bicarbonate, the outcome was fatal.

Findings:

  • Lorcainide overdose can cause life-threatening cardiotoxicity and central nervous system effects.
  • The clinical presentation of lorcainide poisoning resembles that of other Class Ic antiarrhythmic agents.

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  • Rapid and aggressive medical intervention may not prevent fatal outcomes in severe cases.

    • Implications:

    • This case underscores the critical importance of prompt diagnosis and management of antiarrhythmic drug toxicity.
    • It highlights the potential for severe adverse events even with therapeutic agents.
    • Further research into managing severe lorcainide poisoning may be warranted.