Spontaneous retinal changes in Sprague Dawley rats
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Updated: Jul 1, 2026
Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents
Published on: September 16, 2020
M F Hubert1, J P Gillet, G Durand-Cavagna
1Department of Safety Assessment, Centre de Recherche Merck Sharp & Dohme-Chibret, Riom, France.
Abstract:
Routine ophthalmological examination of over 6,000 untreated Crl:CD(SD)BR rats up to 2 years old, used in toxicologic studies from 1989 to 1992, has provided information on spontaneous retinal changes and their incidence with age. Focal linear retinopathy and coloboma were the most common findings; retinal hemorrhage, saccular aneurysm of the retinal vessels, retinal fold, absence of optic disk and retinal vascularization, and myelination of optic nerve fibers were also observed. Such accumulated data in untreated animals are of prime necessity in assessing possible drug- and chemical-induced effects on the eye after either systemic or local exposure.
