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Updated: Aug 18, 2026

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
Published on: June 11, 2017
Cytokines regulate proliferation and cytoskeletal organization of vascular smooth muscle cells
1Gothenburg University, Department of Clinical Chemistry, Sahlgren's Hospital, Sweden.
Abstract:
The vasculature is an important target for inflammatory reactions, which may evolve into subsequent fibrosis. In large vessels, fibrotic lesions develop after invasive manipulations such as angioplasty. This results in stenotic arteries and represents a major clinical problem in cardiology. Local production of cytokines and growth factors both by vascular endothelial and smooth muscle cells and by blood-borne, immunocompetent cells are important regulators of these events. The present review summarizes experimental studies on the role of immune-derived cytokines in vascular cell biology and pathology.
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