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[Rabies in France, 100 years after Pasteur]
1Pasteur Mérieux Sérums et Vaccins, Marnes-la-Coquette.
Presse Medicale (Paris, France : 1983)
|January 14, 1995
Summary
Rabies vaccination, pioneered by Pasteur, is crucial for preventing human rabies. Modern schedules, like the 2-1-1 protocol, offer effective post-exposure prophylaxis against rabies.
Area of Science:
- Infectious Diseases
- Vaccinology
- Public Health
Context:
- Rabies remains a significant public health concern, particularly with the re-emergence of the disease in animal populations.
- International travel and trade increase the risk of rabies transmission across borders.
- The inactivated Pasteur vaccine, cultivated on Vero cell lines, is a key tool in rabies prevention.
Purpose:
- To review the evolution of rabies post-exposure vaccination protocols.
- To compare the traditional 5-dose schedule with the World Health Organization's 2-1-1 schedule.
- To discuss the Centers for Disease Control and Prevention's recommendations for pre-exposure prophylaxis.
Summary:
- The traditional rabies post-exposure vaccination involves 5 intramuscular injections.
- The World Health Organization recommends a 2-1-1 schedule (day 0, 7, 21) for post-exposure vaccination, which has proven effective with modern vaccines.
- Preventive vaccination for high-risk professions involves a different schedule with longer-lasting protection.
Impact:
- Updated vaccination schedules can improve patient compliance and potentially reduce healthcare costs.
- Effective rabies vaccination strategies are essential for preventing human deaths from this zoonotic disease.
- Continued vigilance and collaboration between human and veterinary medicine are vital for rabies control.