Related Experiment Videos
Protection against cisplatin lethality and renal toxicity by chlorpromazine in mice
M Ishikawa1, M Ozaki, Y Takayanagi
1Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Renal Failure
|November 1, 1994
Abstract:
The effect of chlorpromazine on acute lethal toxicity and nephrotoxicity induced by cisplatin was studied in mice. Chlorpromazine (i.p.) given 1 h before cisplatin greatly reduced lethal and renal toxicities of cisplatin, while chlorpromazine did not reduce the antitumor activity of cisplatin against sarcoma 180 in ddY mice or El-4 leukemia in C57BL/6J mice.