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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
[Treatment of tuberculosis in France]
1Service de pneumologie, Groupe hospitalier Pitié-Salpêtrière, Paris.
Abstract:
In France, the treatment of tuberculosis must take into account both the low rate of multiresistance and the relatively low cost of drugs (the cost of 6 months treatment is about equivalent to the cost of 1 day of hospitalization). A six-month regimen has been recommended in France since 1981. Streptomycin is no longer used routinely. A combination of rifampicin, isoniazid and pyrazinamide is the basis of initial treatment either in as a single medication (Rifater) or taken separately. Ethambutol is added at treatment onset, especially when there was a doubt about resistance. The second phase uses isoniazid and rifampicin, together (Rifanah) or separate.
Insights
France recommends a six-month tuberculosis treatment regimen, prioritizing cost-effective drug combinations like rifampicin, isoniazid, and pyrazinamide. This approach addresses low multidrug resistance rates and minimizes hospitalization costs.
Area of Science:
- Infectious Diseases
- Public Health
- Pharmacology
Context:
- Tuberculosis (TB) treatment in France.
- Low rates of multidrug-resistant TB.
- Cost-effectiveness of TB pharmacotherapy compared to hospitalization.
Purpose:
- To outline the current recommended six-month TB treatment regimen in France.
- To detail the drug combinations used in initial and continuation phases of TB therapy.
Summary:
- The French national tuberculosis treatment guideline recommends a six-month regimen.
- Initial treatment combines rifampicin, isoniazid, and pyrazinamide, with ethambutol added if resistance is suspected.
- Continuation therapy involves isoniazid and rifampicin.
Impact:
- Provides a cost-effective and efficient TB treatment strategy for France.
- Guides clinicians in managing tuberculosis with current drug sensitivities.
- Contributes to the global understanding of national TB treatment protocols.
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