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Related Experiment Videos

Torsade de pointes

D M Roden1

  • 1Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-6602.

Clinical Cardiology
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

Torsade de pointes, a dangerous heart rhythm, arises from congenital or drug-induced long QT syndrome. Understanding its mechanism, early afterdepolarizations, guides effective therapies like pacing and magnesium to prevent this arrhythmia.

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Area of Science:

  • Cardiology
  • Pharmacology
  • Electrophysiology

Background:

  • Polymorphic ventricular tachycardia, specifically torsade de pointes, is associated with congenital long QT syndromes and drug-induced QT prolongation.
  • Drugs implicated include antiarrhythmics (quinidine), antihistamines (terfenadine), antibiotics (erythromycin), and neuroleptics (thioridazine).
  • The key electrocardiographic finding is QT(U) lability, influenced by heart rate, in both congenital and acquired long QT syndrome.

Purpose of the Study:

  • To elucidate the underlying mechanisms of torsade de pointes.
  • To correlate basic mechanisms with effective therapeutic strategies.
  • To explore the potential for developing safer antiarrhythmic therapies.

Main Methods:

  • Review of clinical features and basic mechanisms of torsade de pointes.

Related Experiment Videos

  • Analysis of electrocardiographic findings, particularly QT(U) lability.
  • Evaluation of therapeutic interventions targeting heart rate and arrhythmia prevention.

    • Main Results:

    • The primary mechanism is believed to be triggered activity secondary to early afterdepolarizations.
    • Therapeutic approaches include heart rate modulation (pacing, isoproterenol) and arrhythmia prevention (magnesium, beta blockers).
    • Study has defined a novel mechanism for cardiac arrhythmias.

    Conclusions:

    • Understanding the pathophysiology of torsade de pointes is crucial for effective management.
    • Therapies aimed at normalizing heart rate or preventing the arrhythmia are effective.
    • Insights into torsade de pointes mechanisms may lead to improved antiarrhythmic drug development.