Predicting medication compliance in a psychotic population

The compliance level of 42 acutely psychotic inpatients was assessed using a locally constructed standard interview and written questionnaire. Subjects rated their level of compliance and indicated variables that were associated with compliance and noncompliance. Reliable items from the written questionnaire were grouped into five categories: side effects, difficulties obtaining medication, reinforcement for not taking medication, symptom relief, and indirect benefits. A stepwise multiple regression indicated that indirect benefits accounted for 18% of the variance in the self-report measure of compliance. It was concluded that psychotic patients who recognize benefits that are secondary to symptom relief are more likely to comply with their medication regimen. The results suggest a need for research on variables associated with noncompliance and potential treatment interventions.