Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metastatic proclivities and patterns among APUD cell neoplasms

F L Moffat1, A S Ketcham

  • 1Department of Surgery, University of Miami School of Medicine, FL 33101.

Seminars in Surgical Oncology
|September 1, 1993
PubMed
Summary

Neoplasms of APUD cell origin vary in metastasis. Aggressive surgery offers disease-free survival for some patients with these neuroendocrine tumors, even with advanced disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intra-operative use of PET probe for localization of FDG avid lesions.

Cancer imaging : the official publication of the International Cancer Imaging Society·2009
Same author

Breast specimen orientation.

Annals of surgical oncology·2008
Same author

Sentinel node biopsy is not an alternative to axillary dissection in breast cancer.

Journal of surgical oncology·2001
Same author

Dietary olive oil enhances murine lymphocyte calcium uptake.

The Journal of trauma·2000
Same author

Metastasectomy as a cytoreductive strategy for treatment of isolated pulmonary and hepatic metastases from breast cancer.

Surgical oncology·2000
Same author

Introduction: management of cancer in the Canadian Healthcare System.

Cancer investigation·2000

Area of Science:

  • Oncology
  • Endocrinology
  • Pathology

Background:

  • APUD cell-derived neoplasms exhibit diverse metastatic behaviors.
  • Pituitary and parathyroid tumors rarely metastasize, unlike oat cell lung cancers and melanomas.
  • Predicting metastasis in carcinoids, islet cell tumors, and paragangliomas is challenging due to lack of reliable histological markers.

Purpose of the Study:

  • To review the metastatic behavior of APUD cell-derived neoplasms.
  • To highlight the challenges in predicting dissemination risk.
  • To emphasize the prognostic implications of metastatic disease and the role of surgical intervention.

Main Methods:

  • Literature review of APUD cell neoplasms.
  • Analysis of metastatic patterns and prognostic factors.
  • Evaluation of treatment outcomes, particularly surgical resection.

Main Results:

  • Metastatic potential varies significantly among APUD cell tumors.
  • No reliable histological markers currently predict lymphatic or hematogenous spread.
  • Unresectable distant metastases, especially to the liver, indicate a poor prognosis.
  • Mortality is primarily linked to tumor growth and metastasis rather than endocrinopathies.

Conclusions:

  • Aggressive surgical resection (curative or debulking) is recommended.
  • Worthwhile clinical disease-free survival can be achieved in select patients.
  • Understanding metastatic behavior is crucial for managing these neuroendocrine tumors.

Related Experiment Videos