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[Pharmacological analysis of sinus rhythm]
1Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
|October 1, 1993
Summary
Autonomic nervous system factors, bioactive substances, and physicochemical conditions regulate heart rate. This review details mechanisms of bradycardia and tachycardia, including new agents.
Area of Science:
- Cardiovascular Physiology
- Autonomic Nervous System Regulation
Context:
- Sinus node activity is modulated by sympathetic and parasympathetic nervous systems.
- Circulatory substances and physicochemical factors also influence heart rate.
- Understanding these modulators is crucial for cardiovascular health.
Purpose:
- To review the mechanisms of bradycardia and tachycardia.
- To discuss the role of autonomic nervous elements, bioactive substances, and physicochemical factors.
- To introduce newly developed bradycardic agents.
Summary:
- The sinoatrial (SA) node's pacemaker activity is primarily controlled by autonomic nervous system input (sympathetic and parasympathetic).
- Bioactive substances and physicochemical conditions further modify sinus rate, acting directly or indirectly.
- Mechanisms of drug- and nerve-induced bradycardia and tachycardia are examined using canine SA node preparations.
Impact:
- Provides insights into the regulation of heart rate and potential therapeutic targets.
- Highlights advancements in bradycardic agents for managing cardiac conditions.
- Contributes to the understanding of cardiovascular control mechanisms.