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Pituitary adenylate cyclase activating peptide and vasoactive intestinal polypeptide: differentiation effects on
1Laboratory of Environmental Metabolism, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Japan.
Neuroscience Letters
|September 3, 1993
Abstract:
Pituitary adenylate cyclase activating peptide-38 (PACAP-38), PACAP-27 and vasoactive intestinal polypeptide (VIP) increased intracellular cAMP content in human neuroblastoma NB-OK-1 cells transiently. PACAP and VIP also arrested cell growth and induced morphological differentiation, which lasted for 24 h in spite of removal of PACAP-38 and PACAP-27. The order of potencies for the neurite outgrowth and the arrest of cell growth is PACAP-38 > PACAP-27 > VIP. The results suggest the possibility that these neuropeptides are new candidates for differentiation activity.