Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A high recombination frequency within the chicken major histocompatibility (B) complex

B G Hepkema1, M G Tilanus, H J Blankert

  • 1Department of Immunology, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.

Animal Genetics
|October 1, 1993
PubMed
Summary

Researchers identified a tenfold higher recombination frequency in White Leghorn chickens, a significant finding for understanding avian genetics. This study highlights increased genetic diversity within this commercial chicken line.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Symptom Burden and Patient-Reported Outcomes in Kidney Transplant Recipients: Results From the TransplantLines Biobank and Cohort Studies.

Kidney medicine·2026
Same author

Repeated HLA-DRB1 and HLA-DQB1 Mismatches Without Preformed DSA Affect Graft Survival, Rejection and DSA Development: A Multicenter Analysis.

HLA·2025
Same author

Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2018
Same author

THE SPECIFICITY OF ANTI-HLA CLASS II MONOCLONAL ANTIBODIES IN CATTLE.

European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics·2017
Same author

How can we reduce costs of solid-phase multiplex-bead assays used to determine anti-HLA antibodies?

HLA·2016
Same author

Questionable expression of unstable DQ heterodimer containing HLA-DQA1*01:07.

Tissue antigens·2015

Area of Science:

  • Avian genetics
  • Immunogenetics
  • Molecular biology

Background:

  • The Major Histocompatibility Complex (MHC) in chickens, known as the B complex, is crucial for immune response and disease resistance.
  • The B-F and B-G regions within the chicken B complex are highly polymorphic and important for immune function.
  • Understanding recombination frequencies within the B complex is vital for breeding programs and genetic studies.

Purpose of the Study:

  • To determine the frequency of recombination between the B-F and B-G regions in a commercial White Leghorn chicken line.
  • To compare the observed recombination frequency with previously reported values.

Main Methods:

  • Serological typing to identify B-F and B-G alleles.
  • Biochemical methods for genetic analysis.

Related Experiment Videos

  • Molecular biological techniques for precise haplotype determination.

    • Main Results:

    • Out of 287 White Leghorn chickens typed, three animals exhibited recombinant haplotypes.
    • A statistically significant (P < 0.05) tenfold increase in recombination frequency was observed in this specific chicken line compared to earlier studies.
    • This finding suggests a higher rate of genetic exchange within the B complex in this population.

    Conclusions:

    • The commercial White Leghorn line studied shows a significantly elevated rate of recombination within the chicken B complex.
    • This increased recombination frequency may have implications for genetic diversity and immune response in this line.
    • Further research is warranted to explore the factors contributing to this high recombination rate and its impact on chicken breeding.