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Tolerability of levocabastine eye drops
1Janessen Research Foundation, Beerse, Belgium.
Documenta Ophthalmologica. Advances in Ophthalmology
|January 1, 1993
Summary
Levocabastine eye drops, a potent histamine H1 antagonist, demonstrated excellent ocular tolerability in clinical studies. Patients experienced minimal adverse effects, confirming the safety of this treatment for allergic conjunctivitis.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Levocabastine is a potent H1 antagonist used in ophthalmic formulations.
- Ocular formulations often contain preservatives like benzalkonium chloride.
Purpose of the Study:
- To evaluate the local tolerability of levocabastine eye drops.
- To assess the safety profile of levocabastine in ocular applications.
Main Methods:
- Objective measurements included slit lamp examination, tonometry, and staining.
- Subjective assessments involved patient-reported adverse experiences.
- Seven studies involved volunteers and patients with allergic conjunctivitis, comparing levocabastine to placebo or terfenadine.
Main Results:
- No clinically or statistically significant changes were observed in ocular or peri-ocular tissues.
- Subjective reports indicated virtually no local irritation, pain, or tearing.
- Levocabastine eye drops were found to be very well tolerated.
Conclusions:
- Levocabastine eye drops exhibit a favorable ophthalmological safety profile.
- The formulation is well-tolerated for the treatment of ocular conditions like allergic conjunctivitis.