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Acute fluvoxamine poisoning

R Garnier1, P Azoyan, D Chataigner

  • 1Paris Poisons Centre, University of Paris VII, France.

The Journal of International Medical Research
|July 1, 1993
PubMed
Summary
This summary is machine-generated.

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Fluvoxamine overdose is rarely severe, especially below 1000 mg. Symptoms are typically mild, with seizures and cardiotoxicity uncommon even in high-dose fluvoxamine (Selective Serotonin Reuptake Inhibitor) overdoses.

Area of Science:

  • Pharmacology
  • Clinical Toxicology

Background:

  • Selective Serotonin Reuptake Inhibitors (SSRIs) are widely prescribed.
  • Understanding the acute toxicity profile of SSRIs like fluvoxamine is crucial for clinical management.

Purpose of the Study:

  • To analyze the clinical effects and toxicity of deliberate acute fluvoxamine overdose.
  • To assess the severity of fluvoxamine toxicity, particularly in relation to co-ingested substances.

Main Methods:

  • Retrospective analysis of 221 cases reported to the Paris Poison Centre.
  • Inclusion of 78 cases from Duphar BV's International Drug Safety Department.
  • Evaluation of co-ingestion patterns with other substances like benzodiazepines, neuroleptics, other antidepressants, and alcohol.

Main Results:

Related Experiment Videos

  • Fluvoxamine alone rarely caused severe acute toxicity.
  • Doses below 1000 mg typically resulted in benign symptoms (drowsiness, tremor, nausea, vomiting, abdominal pain, bradycardia, anticholinergic effects).
  • Seizures and cardiotoxicity (moderate bradycardia, rare conduction abnormalities) were infrequent and associated with higher doses (>1500 mg).

Conclusions:

  • Acute fluvoxamine overdose generally exhibits low toxicity.
  • Management strategies should consider potential co-ingestions.
  • Fluvoxamine appears to have a relatively safe profile in acute overdose scenarios.