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Diaschisis

J S Meyer1, K Obara, K Muramatsu

  • 1Cerebrovascular Research Laboratory, Department of Veterans Affairs Medical Center, Houston, TX 77030.

Neurological Research
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

Acute brain lesions cause immediate functional deficits in remote areas, a condition called diashisis. Recovery involves synaptic reactivation, aided by rehabilitation, and is linked to restored brain activity.

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Area of Science:

  • Neuroscience
  • Neurology
  • Pathophysiology

Background:

  • Acute, localized central nervous system lesions trigger immediate functional depressions in remote areas.
  • This phenomenon, termed diashisis, results from deafferentation and impacts neuronal synaptic functions.

Purpose of the Study:

  • To elucidate the nature of diashisis and its impact on central nervous system function.
  • To explore the mechanisms of functional recovery following diashisis.

Main Methods:

  • Observational study analyzing neurological signs and symptoms post-lesion.
  • Assessment of local cerebral blood flow and metabolism to understand diashisis's extent.

Main Results:

  • Diashisis manifests as impaired consciousness, cognitive deficits (dementia, dyspraxia, dysphasia), and sensory neglect.

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  • Widespread depressions in local cerebral blood flow and metabolism were observed, extending beyond the initial lesion site.

    • Conclusions:

    • Functional recovery from diashisis is associated with synaptic reactivation and is positively influenced by rehabilitation.
    • Recovery of neurological function correlates with the restoration of local cerebral perfusion and metabolism.