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Immunohistochemical study of c-erbB-2 oncoprotein expression in extramammary Paget's disease
M Nishi1, H Yoshida, M Setoyama
1Department of Dermatology, Faculty of Medicine, Kagoshima University, Japan.
Dermatology (Basel, Switzerland)
|January 1, 1994
Abstract:
Sections of formalin-fixed, paraffin-embedded tumor tissue from 20 patients with noninvasive extramammary Paget's disease and 2 patients with invasive extramammary Paget's disease were stained immunohistochemically by means of anti-c-erbB-2 product monoclonal antibody. Membrane staining of intraepidermal tumor cells was found in only 3 of 20 cases of noninvasive extramammary Paget's disease. In the 2 invasive cases, tumor cells of invasive lesions and metastases were positive while intraepidermal tumor cells were negative.