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HIV-specific CD8+ T-cell immune responses and viral replication
1Unit for Virology and Cellular Immunology, URA CNRS 1157, Pasteur Institute, Paris, France.
AIDS (London, England)
|November 1, 1993
Abstract
Aim:
To review current knowledge of CD8+ T cells in relation to their effect on the replication of HIV and on disease progression.
Present Knowledge:
Both CD8+ cytotoxic T lymphocytes capable of killing cells expressing HIV antigens and CD8+ lymphocytes that suppress HIV replication in vitro are detectable in response to HIV infection.
Conclusion:
These CD8+ T cells may help to maintain a low viral load in vivo, thus allowing a long asymptomatic period of infection.