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Effect of beta-adrenoceptor blockade on post-exercise oxygen consumption
E Børsheim1, R Bahr, P Hansson
1Department of Physiology, National Institute of Occupational Health, Oslo, Norway.
Metabolism: Clinical and Experimental
|May 1, 1994
Summary
Beta-blockers reduce excess post-exercise oxygen consumption (EPOC) by approximately one-third. This suggests catecholamines play a role in the prolonged recovery phase after strenuous exercise.
Area of Science:
- Exercise Physiology
- Cardiovascular Physiology
Background:
- Excess post-exercise oxygen consumption (EPOC) is elevated after strenuous exercise.
- The prolonged component of EPOC is not fully understood, with catecholamines implicated.
Purpose of the Study:
- To investigate the impact of beta-adrenoceptor blockade on EPOC.
- To determine the role of catecholamines in the prolonged EPOC phase.
Main Methods:
- Healthy men underwent randomized exercise trials with and without beta-blockade (propranolol).
- EPOC was measured over 6.5 hours of recovery following a 60-minute exercise bout.
- Resting oxygen uptake was confirmed to be unaffected by propranolol.
Main Results:
- Exercise significantly increased oxygen uptake during recovery without beta-blockade.
- Beta-blockade with propranolol significantly reduced EPOC by about one-third.
- The effect of beta-blockade was primarily on the prolonged component of EPOC.
Conclusions:
- Catecholamines, modulated by beta-adrenoceptors, significantly influence the prolonged recovery of oxygen uptake after exercise.
- Beta-adrenergic blockade attenuates the sustained elevation in oxygen consumption post-exercise.