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[The genotype of CYP2E1 and liver-derived serum enzymes]
K Iwahashi1, R Miyatake, H Suwaki
1Department of Neuropsychiatry, Kagawa Medical School, Japan.
Arukoru Kenkyu to Yakubutsu Izon = Japanese Journal of Alcohol Studies & Drug Dependence
|April 1, 1994
Abstract:
We determined the genotypes of the CYP2E1 loci of Japanese alcoholics with or without liver dysfunction to investigate the relationship between CYP2E1 and the susceptibility to alcoholic liver-injury. In the alcoholics (DSM-III-R) with a liver dysfunction, there was a significant relationship between the serum concentration of a liver-derived serum enzyme LAP and the C2 allele of CYP2E1.