Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circannual variation in lymphocyte subsets, revisited

T G Paglieroni1, P V Holland

  • 1Sacramento Medical Foundation Center for Blood Research, California.

Transfusion
|June 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatitis B, hepatitis C and HIV transfusion-transmitted infections in the 21st century.

Vox sanguinis·2010
Same author

Does donating blood for the first time during a national emergency create a better commitment to donating again?

Vox sanguinis·2009
Same author

TRALI is due to pulmonary venule damage from leucocytes with cholesterol crystal formation.

Vox sanguinis·2009
Same author

Transfusion-associated graft-versus-host disease.

Vox sanguinis·2008
Same author

Selling blood vs. donating blood.

Vox sanguinis·2008
Same author

Hepatitis B virus (HBV) DNA screening of blood donations in minipools with the COBAS AmpliScreen HBV test.

Transfusion·2005

Seasonal variations in CD4+ T-lymphocyte counts were observed in healthy individuals, with counts lowest in summer. This finding is relevant for screening potential blood supply diseases.

Area of Science:

  • Immunology
  • Chronobiology

Background:

  • Previous studies reported circadian and circannual variations in lymphocyte subsets, particularly CD8+ T-lymphocytes.
  • This research specifically investigates the seasonal fluctuations of CD4+ T-lymphocytes over an extended period.

Purpose of the Study:

  • To analyze the seasonal variation in CD4+ T-lymphocyte counts in healthy individuals.
  • To assess the relationship between CD4+ and CD8+ T-lymphocyte counts across seasons.

Main Methods:

  • Monthly quantification of lymphocyte subsets from four healthy individuals over a 6-year, 8-month period (1986-1992).
  • Utilized flow cytometry as part of a quality-control program.

Main Results:

  • No significant seasonal changes were observed in total white blood cell or lymphocyte counts.

Related Experiment Videos

  • CD4+ T-lymphocyte counts were lowest in summer, coinciding with the highest CD8+ T-lymphocyte counts.
  • Three out of four subjects showed a near doubling of B-lymphocyte percentages in winter compared to summer.

    • Conclusions:

    • The observed seasonal variation in CD4+ T-lymphocyte counts in healthy individuals warrants attention.
    • These findings are significant given the ongoing consideration of CD4+ T-lymphocyte counts as a surrogate marker for screening blood supply for AIDS-like diseases.