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Related Experiment Videos

Localized pemphigoid

J R Person, R S Rogers, H O Perry

    The British Journal of Dermatology
    |November 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Localized pemphigoid, a rare skin condition, presents in distinct forms. This study differentiates between scarring plaque-like lesions and localized bullous lesions, offering insights into bullous pemphigoid subtypes.

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    Area of Science:

    • Dermatology
    • Immunodermatology

    Background:

    • Bullous pemphigoid and cicatricial pemphigoid are autoimmune blistering diseases.
    • Localized pemphigoid is a rare variant with distinct clinical presentations.

    Purpose of the Study:

    • To characterize the clinical features and immunofluorescence findings of localized pemphigoid.
    • To differentiate subtypes of localized pemphigoid based on lesion morphology and affected demographics.

    Main Methods:

    • Retrospective review of nine localized pemphigoid cases seen at Mayo Clinic (1968-1975).
    • Analysis of clinical presentation, disease evolution, and immunofluorescence results (direct and indirect).

    Main Results:

    • Two distinct types of localized pemphigoid were identified: scarring plaque-like lesions (head/neck, males) and localized bullous lesions (lower legs, females).

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  • One case evolved into bullous pemphigoid with positive indirect immunofluorescence.
  • Direct immunofluorescence showed linear C3 and fibrin deposition in three of five patients; two were negative.

    • Conclusions:

    • Localized pemphigoid can be classified into two distinct clinical subtypes.
    • Immunofluorescence findings in localized pemphigoid can be variable, including negative results or deposition of complement and fibrin without immunoglobulins.