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Conserved homeobox genes in the developing brain

E Boncinelli1, M Gulisano, M Pannese

  • 1Istituto Scientifico H.S. Raffaele, Milano, Italy.

Comptes Rendus De L'Academie Des Sciences. Serie III, Sciences De La Vie
|September 1, 1993
PubMed
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Four homeobox genes (Emx1, Emx2, Otx1, Otx2) show sequential expression in the developing mouse brain, suggesting roles in establishing embryonic cell fates.

Area of Science:

  • Developmental biology
  • Neuroscience
  • Genetics

Background:

  • Homeobox genes are crucial for embryonic development.
  • The Drosophila genes empty spiracles and orthodenticle have conserved roles in head development.
  • Understanding the expression patterns of these genes in mice can elucidate brain development.

Purpose of the Study:

  • To analyze the expression patterns of four mouse homeobox genes (Emx1, Emx2, Otx1, Otx2) in the developing brain.
  • To investigate the temporal and spatial regulation of these genes during embryogenesis.
  • To infer the roles of these genes in establishing cell fates in the embryonic brain.

Main Methods:

  • Analysis of gene expression in E10 mouse embryos.
  • Utilizing techniques to detect transcript localization and timing.

Related Experiment Videos

  • Comparative analysis with Drosophila developmental genes.

    • Main Results:

    • All four genes (Emx1, Emx2, Otx1, Otx2) are expressed in specific domains within the developing rostral brain.
    • Expression domains are nested, following the sequence Emx1 < Emx2 < Otx1 < Otx2.
    • Gene transcript appearance is sequential, starting with Otx2, then Otx1 and Emx2, and finally Emx1.

    Conclusions:

    • These homeobox genes play a progressive role in establishing cell fates within distinct embryonic brain regions.
    • The dorsal telencephalon appears to be a central region for this process.
    • The structural organization and regulation of these genes are evolutionarily conserved.