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Macromolecular crowding and molecular recognition
1Section on Physical Biochemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
Journal of Molecular Recognition : JMR
|December 1, 1993
Abstract:
The effects of macromolecular crowding upon macromolecular associations in solution, and upon binding of a macromolecular ligand to a surface site, are reviewed. It is demonstrated, by means of two examples, that crowding may lead to significant alterations of biochemical or biological recognition processes at the molecular level.
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