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Related Experiment Videos

Encephalitis--an adverse reaction to fenbufen

B A Crosse1, P J Stanley

  • 1Department of Infectious Diseases, Seacroft Hospital, Leeds.

The British Journal of Clinical Practice
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

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A young woman

Area of Science:

  • Neurology
  • Dermatology
  • Rheumatology

Background:

  • A patient presented with symptoms suggestive of an enteroviral infection, including encephalitis and a generalized skin rash.
  • The patient had a history of mixed connective tissue disease.

Observation:

  • Despite initial suspicion of enteroviral infection, no infectious agent was identified.
  • The patient developed encephalitis and a generalized skin rash.

Findings:

  • The illness was attributed to an adverse reaction to the nonsteroidal anti-inflammatory drug fenbufen.
  • The adverse reaction occurred on a background of mixed connective tissue disease.

Implications:

  • This case highlights the importance of considering drug-induced reactions in the differential diagnosis of encephalitis and rash.

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  • It underscores the potential for fenbufen to cause severe adverse events, particularly in patients with underlying autoimmune conditions.
  • Clinicians should maintain a high index of suspicion for drug reactions when evaluating complex presentations in patients with connective tissue diseases.