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Treatment of refractory T-cell chronic lymphocytic leukemia with purine nucleoside analogues
T E Witzig1, J J Weitz, J H Lundberg
1Division of Internal Medicine and Hematology, Mayo Clinic, Rochester, Minnesota 55905.
Abstract:
This report describes two cases of T-cell chronic lymphocytic leukemia (T-CLL) treated with purine nucleoside analogues. One patient had CD8+, CD3+ large granular lymphocytosis (LGL) producing transfusion-dependent anemia and was refractory to chemotherapy. Treatment with four cycles of fludarabine produced a clinical complete remission and a molecular genetic partial remission that has been durable for > 15 months. The other patient had CD4+ T-prolymphocytic leukemia and was unresponsive to both fludarabine and 2-chlorodeoxyadenosine. Further trials of these agents are warranted in T-CLL, especially the LGL variant.