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Related Experiment Videos

New challenges in the growth field

C J DeVile1, A Albanese, B Thomas

  • 1Institute of Child Health, London, U.K.

The Journal of Pediatric Endocrinology
|July 1, 1993
PubMed
Summary
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Biosynthetic human growth hormone (hGH) offers limited height increase for most short children with growth disorders. Exceptions include girls with Turner

Area of Science:

  • Pediatrics
  • Endocrinology
  • Genetics

Background:

  • Biosynthetic human growth hormone (hGH) availability in the late 1980s raised expectations for treating short stature.
  • Early therapeutic applications focused on increasing final height in children with growth disorders.

Purpose of the Study:

  • To evaluate the effectiveness of pharmacological doses of human growth hormone (hGH) in increasing final height for children with various growth disorders.
  • To identify challenges in growth hormone (GH) therapy, including the manipulation of pubertal development.

Main Methods:

  • Retrospective analysis of growth data from children treated with hGH.
  • Comparative study of height outcomes in different growth disorder populations.
  • Review of hormonal and developmental responses to GH therapy.

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Main Results:

  • Pharmacological doses of hGH did not significantly increase final height in most children with growth disorders.
  • Girls with Turner's syndrome showed a notable positive response to hGH therapy.
  • Managing pubertal development alongside GH therapy presents ongoing challenges.

Conclusions:

  • The therapeutic potential of hGH for increasing final height in short children is less than initially envisaged, with notable exceptions.
  • Turner's syndrome is a key indication where hGH therapy demonstrates significant efficacy.
  • Further research is needed to optimize GH treatment protocols, particularly concerning pubertal manipulation.