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Changes in plasma calcium during septic shock

A D Cumming1

  • 1University Department of Medicine, Royal Infirmary, Edinburgh, United Kingdom.

Journal of Accident & Emergency Medicine
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

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Septic shock in sheep models causes significant decreases in plasma calcium levels, even after correcting for albumin. This finding may contribute to understanding sepsis pathophysiology.

Area of Science:

  • Physiology
  • Biochemistry
  • Pathology

Background:

  • Decreased plasma calcium is observed after trauma, hemorrhage, and cardiac arrest.
  • Septic shock can lead to significant physiological disturbances.

Purpose of the Study:

  • To investigate changes in plasma calcium in an ovine model of septic shock.
  • To determine if plasma calcium reduction is linked to sepsis severity.

Main Methods:

  • Ovine model of intraperitoneal sepsis induced surgically.
  • Volume loading with Ringer's lactate solution.
  • Measurement of plasma calcium and albumin before and 24 hours after sepsis induction.

Main Results:

  • Plasma calcium significantly decreased in both severe and non-severe sepsis groups (P < 0.001).

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  • Albumin levels also decreased, with a greater reduction in the severe sepsis group.
  • Albumin-corrected plasma calcium remained significantly reduced in both groups.

    • Conclusions:

    • Significant decrements in plasma calcium occur in a large animal model of septic shock.
    • These calcium changes may play a role in the pathophysiology of sepsis.
    • The findings highlight the importance of monitoring calcium levels in septic patients.