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The natriuretic peptide family

K Nakao1, H Itoh, S Suga

  • 1Department of Medicine, Kyoto University School of Medicine, Japan.

Current Opinion in Nephrology and Hypertension
|January 1, 1993
PubMed
Summary

The natriuretic peptide system, involving key peptides and receptors, regulates blood pressure and fluid balance. This system acts as both a cardiac hormone and local regulator in the body.

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Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Molecular Biology

Background:

  • The natriuretic peptide system comprises three peptides: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP).
  • It also includes three receptors: atrial natriuretic peptide-A receptor (NPR-A/GC-A), atrial natriuretic peptide-B receptor (NPR-B/GC-B), and a clearance receptor (NPR-C).

Purpose of the Study:

  • To elucidate the multifaceted roles of the natriuretic peptide system.
  • To understand its involvement in cardiovascular regulation and fluid homeostasis.

Main Methods:

  • Review of accumulated scientific evidence.
  • Analysis of the system's components and functions.

Main Results:

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  • The natriuretic peptide system is crucial for controlling blood pressure.
  • It plays a significant role in maintaining body fluid homeostasis.
  • The system is implicated in vascular remodeling processes.

Conclusions:

  • The natriuretic peptide system functions as both a circulating cardiac hormone and a local regulator.
  • This system is vital for integrated physiological control of the cardiovascular system and fluid balance.