Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glomerulonephritis

G Remuzzi1, C Zoja, T Bertani

  • 1Mario Negri Institute for Pharmacological Research, Bergamo, Italy.

Current Opinion in Nephrology and Hypertension
|May 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Imatinib ameliorates renal disease and survival in murine lupus autoimmune disease.

Kidney international·2006
Same author

Genetics of rare diseases of the kidney: learning from mouse models.

Cytogenetic and genome research·2004
Same author

The role of the endothelium in hemolytic uremic syndrome.

Journal of nephrology·2002
Same author

Verotoxin-1-induced up-regulation of adhesive molecules renders microvascular endothelial cells thrombogenic at high shear stress.

Blood·2001
Same author

Mycophenolate mofetil combined with a cyclooxygenase-2 inhibitor ameliorates murine lupus nephritis.

Kidney international·2001
Same author

Protein traffic activates NF-kB gene signaling and promotes MCP-1-dependent interstitial inflammation.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2000
Same journal

Updates in management of cardiorenal syndrome.

Current opinion in nephrology and hypertension·2026
Same journal

Sex differences in renal acid-base regulation.

Current opinion in nephrology and hypertension·2026
Same journal

Primary prevention of chronic kidney disease in type 2 diabetes mellitus with sodium-glucose cotransporter 2 inhibitors.

Current opinion in nephrology and hypertension·2026
Same journal

Financial and policy challenges of delivering kidney replacement therapies in resource-limited settings.

Current opinion in nephrology and hypertension·2026
Same journal

The role of kir4.1/Kir5.1 in mediating the effect of angiotensin-II on Na-Cl-cotransporter.

Current opinion in nephrology and hypertension·2026
Same journal

Role of the calcium-sensing receptor in regulating calcium transport in the thick ascending limb.

Current opinion in nephrology and hypertension·2026
See all related articles

New insights into glomerular injury mechanisms are emerging from cell and molecular biology. Targeting cell adhesion molecules and understanding protein toxicity may revolutionize glomerulonephritis treatment.

Area of Science:

  • Nephrology
  • Immunology
  • Cell Biology

Background:

  • Glomerular injury mechanisms have seen limited advances in the last two decades.
  • Recent research focuses on identifying renal antigens and understanding immune cell roles in glomerulonephritis.

Purpose of the Study:

  • To review recent advances in understanding glomerular injury.
  • To highlight the impact of cell adhesion, cytokines, and protein excretion on kidney disease.

Main Methods:

  • Review of current literature on cell and molecular biology of glomerular injury.
  • Analysis of studies on immune cell function, cell adhesion molecules, and protein handling in the kidney.

Main Results:

  • Identification of specific renal antigens involved in immune reactions.

Related Experiment Videos

  • Demonstration that cell adhesion molecules mediate inflammatory cell damage in glomeruli.
  • Evidence from animal models shows blocking antibodies reduce glomerular damage.
  • Cytokines and growth factors influence injury and scarring.
  • Glomerular injury is linked to urinary protein excretion and proximal tubule toxicity.
  • Tubulointerstitial injury correlates with glomerular damage and renal scarring.

    • Conclusions:

    • Advances in cell and molecular biology offer new therapeutic targets for glomerular diseases.
    • Understanding cell adhesion and protein toxicity is crucial for managing glomerulonephritis and preventing renal scarring.