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Atherosclerosis in chronic renal failure

D I Charney1, D F Walton, A K Cheung

  • 1University of Utah, Salt Lake City.

Current Opinion in Nephrology and Hypertension
|November 1, 1993
PubMed
Summary
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Atherosclerosis is a major concern for patients with chronic kidney disease. This review examines whether kidney failure accelerates cardiovascular disease and identifies contributing factors in uremic patients.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Pathology

Background:

  • Atherosclerotic cardiovascular disease is a leading cause of death in patients with chronic renal failure.
  • The incidence and rate of atherosclerosis in chronic renal failure patients compared to the general population remain unclear.
  • The precise nature of atherosclerotic lesions in chronic renal failure is not well-defined.

Purpose of the Study:

  • To review the pathology of atherosclerotic lesions in chronic renal failure.
  • To explore factors contributing to atherogenesis in uremic patients.
  • To evaluate evidence for accelerated atherosclerosis in end-stage renal disease.

Main Methods:

  • Literature review of existing studies on atherosclerosis in chronic renal failure.

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  • Discussion of pathological findings and contributing factors.
  • Analysis of data comparing atherosclerosis rates in uremic versus non-uremic populations.

    • Main Results:

    • Chronic renal failure is associated with significant cardiovascular morbidity and mortality.
    • The uremic state, dialysis, and other factors may contribute to atherogenesis.
    • Evidence suggests atherosclerosis may be accelerated in patients with end-stage renal disease.

    Conclusions:

    • Further research is needed to clarify the incidence and progression of atherosclerosis in chronic renal failure.
    • Identifying and mitigating risk factors for accelerated atherosclerosis is crucial for improving outcomes in uremic patients.
    • Understanding the specific role of the uremic milieu in atherogenesis is essential.