Combinatorial libraries. Finding the needle in the haystack

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High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
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High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

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R A Houghten1

  • 1Houghten Pharmaceuticals, Inc., San Diego, California.

Current Biology : CB
|June 1, 1994
PubMed

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Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
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