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Reflux nephropathy and pregnancy

P Jungers1

  • 1Université René Descartes, Hôpital Necker, Paris, France.

Bailliere'S Clinical Obstetrics and Gynaecology
|June 1, 1994
PubMed
Summary
This summary is machine-generated.

Women with reflux nephropathy face risks during pregnancy, especially with impaired kidney function. Aiming for conception before plasma creatinine exceeds 0.20 mmol/L is crucial for successful pregnancy and disease progression.

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Area of Science:

  • Nephrology
  • Obstetrics
  • Urology

Background:

  • Reflux nephropathy is a common renal disease in women of childbearing age.
  • The condition can be asymptomatic until pregnancy, presenting as UTIs, proteinuria, or hypertension.
  • Severe disease may lead to chronic renal failure and recurrent pyelonephritis.

Purpose of the Study:

  • To evaluate the impact of reflux nephropathy on pregnancy outcomes.
  • To identify risk factors for adverse pregnancy and renal outcomes.
  • To provide guidance for conception in women with reflux nephropathy.

Main Methods:

  • Observational study analyzing pregnant women with reflux nephropathy.
  • Assessment of renal function (plasma creatinine) and blood pressure at conception.

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  • Correlation of maternal and fetal outcomes with pre-conception renal function and hypertension.

    • Main Results:

    • Normal renal function and absence of hypertension at conception lead to successful pregnancies.
    • Impaired renal function (creatinine > 0.20-0.22 mmol/L), especially with hypertension, significantly increases risks.
    • High risk of fetal growth retardation, intrauterine death, and accelerated renal failure progression in high-risk pregnancies.

    Conclusions:

    • Women with reflux nephropathy should conceive before plasma creatinine reaches 0.20 mmol/L.
    • Patients with elevated creatinine levels must be counseled on high risks to pregnancy and renal disease progression.
    • Early intervention and careful monitoring are essential for managing reflux nephropathy during pregnancy.