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[Significance of periventricular hyper-intensity in T2 weighted MRI on memory dysfunction and depression after
H Bokura1, S Kobayashi, S Yamaguchi
1Third Division of Internal Medicine, Shimane Medical University.
Abstract:
We studied the effect of periventricular hyperintensity (PVH) in T2 weighted MRI on memory function and post-stroke depression in 159 patients with cerebrovascular diseases. Memory function was assessed with Hasegawa's scale, and depressive state was estimated with Zung's self-rating depression scale. Patients showing diffusely distributed PVH had significantly low scores in memory function tests. Localized PVH around the anterior horns of the laterals ventricle was also associated with impaired memory function when the area of PVH was large. The incidence of post-stroke depression was high in patients with large PVH around the anterior horn in comparison with patients with PVH around the posterior horn. The severity of PVH around the posterior horn did not affect memory function and post-stroke depression. These findings suggest that memory dysfunction and post-stroke depression were accelerated by the diffusely or anteriorly distributed PVH.
Insights
Diffuse or anterior periventricular hyperintensity (PVH) on MRI significantly impairs memory function and increases post-stroke depression. Posterior PVH showed no such effects. This highlights the impact of PVH location on cognitive and emotional outcomes after cerebrovascular disease.
Area of Science:
- Neurology
- Radiology
- Neuropsychology
Background:
- Periventricular hyperintensity (PVH) on T2-weighted MRI is a common finding in patients with cerebrovascular diseases.
- The clinical significance of PVH, particularly its impact on cognitive function and mood, requires further elucidation.
Purpose of the Study:
- To investigate the association between periventricular hyperintensity (PVH) distribution and severity on T2-weighted MRI with memory function and post-stroke depression.
- To determine if the location and extent of PVH influence cognitive decline and depressive symptoms in patients with cerebrovascular diseases.
Main Methods:
- Assessed memory function using Hasegawa's scale and depressive state with Zung's self-rating depression scale in 159 patients with cerebrovascular diseases.
- Analyzed T2-weighted MRI scans to evaluate the distribution (diffuse, anterior, posterior) and severity of periventricular hyperintensity (PVH).
- Correlated MRI findings of PVH with cognitive and depressive scores.
Main Results:
- Patients with diffusely distributed PVH demonstrated significantly lower scores on memory function tests.
- Localized PVH around the anterior horns of the lateral ventricles, especially when extensive, was linked to impaired memory function.
- A higher incidence of post-stroke depression was observed in patients with large PVH around the anterior horns compared to those with posterior horn PVH.
- The severity of PVH around the posterior horn did not significantly affect memory function or post-stroke depression.
Conclusions:
- Diffuse or anteriorly located periventricular hyperintensity (PVH) on MRI is associated with accelerated memory dysfunction.
- Anteriorly distributed PVH, particularly when extensive, is linked to an increased risk of post-stroke depression.
- The location, not just the severity, of PVH is a critical factor in predicting cognitive and emotional outcomes in cerebrovascular disease patients.