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Reference intervals for some biochemical parameters in the aged Kenyan population

M J Mbiti1, D A Orinda, P J Ojwang

  • 1Department of Clinical Chemistry Kenyatta National Hospital, University of Nairobi, Kenya.

East African Medical Journal
|February 1, 1994
PubMed
Summary

This study establishes reference intervals for key serum electrolytes and metabolites in elderly Kenyans. Findings reveal lower sodium and calcium levels, and higher inorganic phosphate compared to temperate populations.

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Area of Science:

  • Clinical Chemistry
  • Geriatric Medicine
  • Public Health

Background:

  • Establishing age-specific and population-specific reference intervals is crucial for accurate clinical diagnosis.
  • Previous research has not comprehensively defined serum electrolyte and metabolite reference ranges for the elderly Kenyan population.

Purpose of the Study:

  • To determine the reference intervals for serum sodium, potassium, calcium, inorganic phosphate, urea nitrogen, and creatinine in Kenyan adults aged 50 years and above.
  • To compare these reference intervals with those established for other populations, particularly those in temperate environments.

Main Methods:

  • Serum samples from 1101 males and 181 females aged 50+ were analyzed using the SMA II analyzer.
  • Analytical methods underwent rigorous quality control.

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  • Reference intervals were calculated using a simple statistical method.

    • Main Results:

    • Established reference intervals for sodium (131-142 mMol/L) and calcium (1.94-2.32 mMol/L) were found to be lower in the elderly Kenyan population compared to temperate populations.
    • The reference interval for inorganic phosphate (1.2-1.97 mMol/L) was comparatively higher.
    • Reference values for urea nitrogen, potassium, and creatinine were similar to those reported for Caucasian populations.

    Conclusions:

    • The study provides essential reference intervals for key biochemical parameters in elderly Kenyans.
    • Significant differences in sodium, calcium, and inorganic phosphate levels highlight the need for population-specific reference ranges.
    • These findings contribute to improved diagnostic accuracy and clinical management of elderly individuals in Kenya.