Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Capillary pressure in patients with NIDDM

A C Shore1, A J Jaap, J E Tooke

  • 1Department of Vascular Medicine, Postgraduate Medical School, University of Exeter, U.K.

Diabetes
|October 1, 1994
PubMed
Summary

Capillary pressure was not elevated in patients with non-insulin-dependent diabetes mellitus (NIDDM), contrary to findings in insulin-dependent diabetes. This suggests different mechanisms in diabetic microangiopathy pathogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Volatomics for Diagnosis and Risk Stratification of MASLD: A Proof-Of-Concept Study.

Alimentary pharmacology & therapeutics·2025
Same author

Meticillin-susceptible Staphylococcus aureus transmission among healthcare workers, patients and the environment in a large acute hospital under non-outbreak conditions investigated using whole-genome sequencing.

The Journal of hospital infection·2022
Same author

Meticillin-resistant Staphylococcus aureus transmission among healthcare workers, patients and the environment in a large acute hospital under non-outbreak conditions investigated using whole-genome sequencing.

The Journal of hospital infection·2021
Same author

The novel collagen matrikine, endotrophin, is associated with mortality and cardiovascular events in patients with atherosclerosis.

Journal of internal medicine·2021
Same author

Multiple distinct outbreaks of Panton-Valentine leucocidin-positive community-associated meticillin-resistant Staphylococcus aureus in Ireland investigated by whole-genome sequencing.

The Journal of hospital infection·2020
Same author

Renal nitrate clearance in chronic kidney disease.

Nitric oxide : biology and chemistry·2020

Area of Science:

  • Endocrinology
  • Vascular Biology
  • Diabetology

Background:

  • Diabetic microangiopathy is a complication of diabetes mellitus.
  • The hemodynamic hypothesis posits raised capillary pressure in its pathogenesis.
  • Differences in microvascular complications between insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM) suggest varied pathogenic mechanisms.

Purpose of the Study:

  • To investigate whether capillary pressure is elevated in patients with NIDDM.
  • To compare capillary pressure in NIDDM patients with healthy controls.

Main Methods:

  • Finger nailfold capillary pressure was measured in 21 NIDDM patients and 21 matched healthy controls.
  • Measurements were taken using direct cannulation of capillary loops with glass micropipettes.
  • Groups were matched for age, sex, skin temperature, systolic blood pressure, and diastolic blood pressure.

Main Results:

  • Capillary pressure did not significantly differ between NIDDM patients (17.6 mmHg) and control subjects (19.1 mmHg).
  • No correlation was found between capillary pressure and HbA1c or glucose levels.
  • A negative association was observed between capillary pressure and diabetes duration (Rs = -0.50, P = 0.020).

Conclusions:

  • Raised capillary pressure is not a feature of NIDDM, unlike in IDDM.
  • The pathogenesis of microvascular complications in NIDDM may involve mechanisms other than elevated capillary pressure.

Related Experiment Videos