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[Delirium--state of research]
1Klinik für Psychiatrie, Medizinische Universität zu Lübeck.
Fortschritte Der Neurologie-Psychiatrie
|August 1, 1994
Summary
Delirium, a common acute organic psychosis in the elderly, has high mortality but limited research. This review covers its psychopathology, pathogenesis, epidemiology, diagnostics, and therapy, highlighting complex causal factors.
Area of Science:
- Geriatric Medicine
- Neuroscience
- Psychiatry
Context:
- Delirium is the most frequent acute organic psychosis, particularly affecting the elderly population.
- High mortality rates associated with delirium underscore its clinical significance.
- Limited intensive research has contributed to a knowledge gap regarding delirium.
Purpose:
- To review recent literature on delirium, focusing on key aspects.
- To explore the psychopathology, pathogenesis, epidemiology, diagnostics, and therapeutic strategies for delirium.
Summary:
- The pathogenesis of delirium is not uniform, with neurotransmitter, hormone, and electrolyte imbalances likely playing significant roles.
- Complex interactions and rebound phenomena from substance withdrawal may contribute to delirium development.
- Cerebral metabolic changes resulting from brain or somatic disorders are considered a primary cause of delirium.
Impact:
- This review aims to consolidate current knowledge and guide future research into delirium.
- Understanding the multifaceted pathogenesis is crucial for developing effective diagnostic and therapeutic interventions.
- Improved knowledge of delirium can lead to better patient outcomes and reduced mortality in at-risk populations.