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Graft-versus-host disease: introduction and prospect
In order to devise the way of prevention and the progress in the treatment of transfusion-associated graft-versus-host disease (TA-GVHD), this issue is published as the results of the symposium on GVHD at Fukushima Medical College, 1992. HLA analyses of TA-GVHD forced us to alter our concept of mechanism of this disease. As one-way matching in HLA from donor to recipient is important in developing the TA-GVHD, transfusions between relatives are most hazardous and there is a higher risk even unrelated donors in Japanese. Prophylactic irradiation of blood components is the method of inactivating immunocompetent lymphocytes and is nowadays the most effective in preventing the TA-GVHD. In the future we will have leukocyte depletion filters of next generation and ultraviolet irradiation on platelet concentrates as alternative to irradiation.
In order to devise the way of prevention and the progress in the treatment of transfusion-associated graft-versus-host disease (TA-GVHD), this issue is published as the results of the symposium on GVHD at Fukushima Medical College, 1992. HLA analyses of TA-GVHD forced us to alter our concept of mechanism of this disease. As one-way matching in HLA from donor to recipient is important in developing the TA-GVHD, transfusions between relatives are most hazardous and there is a higher risk even unrelated donors in Japanese. Prophylactic irradiation of blood components is the method of inactivating immunocompetent lymphocytes and is nowadays the most effective in preventing the TA-GVHD. In the future we will have leukocyte depletion filters of next generation and ultraviolet irradiation on platelet concentrates as alternative to irradiation.