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Related Experiment Videos

Ketorolac (Toradol) induced lithium toxicity

V Iyer1

  • 1Department of Neurology, University of Louisville, KY 40292.

Headache
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

A patient experienced lithium neurotoxicity when given ketorolac alongside lithium for cluster headaches. This case highlights a potential drug interaction not previously documented between lithium and ketorolac, a type of nonsteroidal anti-inflammatory drug.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Nephrology

Background:

  • Lithium is a common treatment for bipolar disorder.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used for pain management.
  • Drug interactions between lithium and NSAIDs can lead to lithium toxicity.

Observation:

  • A patient with cluster headaches was treated with lithium and ketorolac.
  • Ketorolac is an NSAID that has not been previously implicated in lithium interactions.
  • The patient developed symptoms of lithium neurotoxicity.

Findings:

  • The coadministration of ketorolac and lithium resulted in lithium neurotoxicity.
  • This case suggests a potential drug interaction between ketorolac and lithium.
  • Lithium levels were likely elevated due to ketorolac's effect on renal lithium clearance.

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Implications:

  • Clinicians should be aware of the potential for lithium neurotoxicity when prescribing ketorolac to patients on lithium therapy.
  • Further research is needed to elucidate the mechanism of this interaction.
  • This finding may necessitate a reevaluation of NSAID use in patients receiving lithium.