Related Experiment Videos
Synthesis of doxorubicin-cyclodextrin conjugates
H Tanaka1, K Kominato, R Yamamoto
1Central Research Laboratories, Mercian Corporation, Kanagawa, Japan.
The Journal of Antibiotics
|September 1, 1994
Abstract:
Doxorubicin-gamma-cyclodextrin conjugates have been synthesized by the coupling of 14-bromodaunomycin with mono half-ester compounds linked to a 6-hydroxyl group of gamma-cyclodextrin. Release of drug from the conjugates in saline phosphate buffer solution and in vitro antitumor activity against L1210 leukemia cells were also investigated.