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PEEP ventilation does not cause humorally mediated cardiac output depression in pigs
J E Berglund1, E Haldén, S Jakobson
1Department of Anaesthesiology, University Hospital, Uppsala, Sweden.
Objective:
This study was designed to see if humorally mediated negative inotropism contributes to the cardiac output (CO) depression seen during positive end-expiratory pressure (PEEP) ventilation.
Design:
8 pairs of piglets were used and a combined blood circulation was established between the two animals in each pair. One animal was ventilated with a PEEP of 15 cmH20 (donor) and the other was ventilated without PEEP (recipient).
Measurement And Results:
CO and stroke volume deteriorated in the donors by 32% and 44%, respectively, while no change was seen in the recipients.
Conclusion:
As humorally mediated negative inotropism during PEEP ventilation has earlier been demonstrated in dogs, the results suggest that this mechanism might be species-dependent.